Translational Research

We develop translational projects in close collaboration with clinicians specialized in liver diseases.


Within the team, we have a long standing expertise on:
• fibrosis (V. De Ledinghen)
• hepatocellular adenoma (P. Bioulac-Sage, C. Balabaud)

We also develop projects that aim to :

• identify biomarkers of Sorafenib efficiency (JF. Blanc/F. Saltel)



Frederic SALTEL, DR Inserm
Anne-Aurélie RAYMOND, IR Inserm
Jean-Frédéric BLANC, PU-PH - Liver Oncologist (Bordeaux)
Charles BALABAUD, PU-PH Emeritus - Hepatologist
Paulette BIOULAC-SAGE, PU-PH Emeritus - Liver Pathologist
Brigitte LE BAIL, PU-PH - Liver Pathologist (Bordeaux CHU)
Victor DE LEDINHGEN, PU-PH - Hepatologist (Bordeaux CHU)


Main publications

J. Putra, L. D. Ferrell, A. S. H. Gouw, V. Paradis, A. Rishi, C. Sempoux, C. Balabaud, S. N. Thung, P. Bioulac-Sage, Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon, Mod. Pathol. 2020, 33, 665–675.

S. Shili-Masmoudi, G. L.-H. Wong, J.-B. Hiriart, K. Liu, F. Chermak, S. S.-T. Shu, J. Foucher, Y.-K. Tse, P.-H. Bernard, T. C.-F. Yip, W. Merrouche, H. L.-Y. Chan, V. W.-S. Wong, V. de Lédinghen, Liver stiffness measurement predicts long-term survival and complications in non-alcoholic fatty liver disease, Liver Int. 2020; 40, 581–589.

J. Boursier, M. Guillaume, V. Leroy, M. Irlès, M. Roux, A. Lannes, J. Foucher, F. Zuberbuhler, C. Delabaudière, J. Barthelon, S. Michalak, J.-B. Hiriart, J.-M. Peron, T. Gerster, B. Le Bail, J. Riou, G. Hunault, W. Merrouche, F. Oberti, L. Pelade, I. Fouchard, C. Bureau, P. Calès, V. de Ledinghen, New sequential combinations of non-invasive fibrosis tests provide an accurate diagnosis of advanced fibrosis in NAFLD, J. Hepatol. 2019; 71, 389–396.

N. Frulio, C. Balabaud, C. Laurent, H. Trillaud, P. Bioulac-Sage, Unclassified hepatocellular adenoma expressing ASS1 associated with inflammatory hepatocellular adenomas, Clin Res Hepatol Gastroenterol 2019; 43, e63–e67.

V. W.-S. Wong, M. Irles, G. L.-H. Wong, S. Shili, A. W.-H. Chan, W. Merrouche, S. S.-T. Shu, J. Foucher, B. Le Bail, W. K. Chan, H. L.-Y. Chan, V. de Ledinghen, Unified interpretation of liver stiffness measurement by M and XL probes in non-alcoholic fatty liver disease, Gut 2019; 68, 2057–2064.

Sempoux C, Balabaud C, Paradis V, Bioulac-Sage P. Hepatocellular nodules in vascular liver diseases. Virchows Arch. 2018 May 26. doi:10.1007/s00428-018-2373-6.

van Leeuwen DJ, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, Colombari R, Crawford JM, Dhillon AP, Ferrell L, Gill RM, Guido M, Hytiroglou P, Nakanuma Y, Paradis V, Rautou PE, Sempoux C, Snover DC, Theise ND, Thung SN, Tsui WMS, Quaglia A, Liver Pathology Study Group TI. Acute-on-chronic liver failure 2018: a need for (urgent) liver biopsy? Expert Rev Gastroenterol Hepatol. 2018 Jun;12(6):565-573.

Sempoux C, Bioulac-Sage P. Vascular liver lesions: contemporary views on long-recognized entities. Virchows Arch. 2018 Mar 14. doi:10.1007/s00428-018-2328-y.

Balabaud C, Laurent C, Le Bail B, Castain C, Possenti L, Frulio N, Chiche L, Blanc JF, Bioulac-Sage P. Unexpected discovery of small HNF1α-inactivated hepatocellular adenoma in pathological specimens from patients resected for liver tumours. Liver Int. 2018 Jul;38(7):1273-1279.

Saldarriaga J, Bisig B, Couchy G, Castain C, Zucman-Rossi J, Balabaud C, Sempoux C, Bioulac-Sage P. Focal β-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas. Histopathology. 2017 Dec;71(6):989-993.

Bioulac-Sage P, Sempoux C, Balabaud C. Hepatocellular Adenomas: Morphology and Genomics. Gastroenterol Clin North Am. 2017 Jun;46(2):253-272.

Bioulac-Sage P, Sempoux C, Balabaud C. Hepatocellular adenoma: Classification, variants and clinical relevance. Semin Diagn Pathol. 2017 Mar;34(2):112-125.

Sempoux C, Bisig B, Couchy G, Balabaud C, Zucman-Rossi J, Bioulac-Sage P. Malignant transformation of a b-catenin inflammatory adenoma due to a S45 ß-catenin activating mutation present 12 years before. Hum Pathol. 2017 Apr;62:122-125.

Boursier J, Vergniol J, Guillet A, Hiriart JB, Lannes A, Le Bail B, Michalak S, Chermak F, Bertrais S, Foucher J, Oberti F, Charbonnier M, Fouchard-Hubert I, Rousselet MC, Calès P, de Lédinghen V. Diagnostic accuracy and prognostic significance of blood fibrosis tests and liver stiffness measurement by FibroScan in non-alcoholic fatty liver disease. J Hepatol. 2016 Sep;65(3):570-8.

Petta S, Wai-Sun Wong V, Cammà C, Hiriart JB, Wong GL, Marra F, Vergniol J, Chan AW, Di Marco V, Merrouche W, Chan HL, Barbara M, Le-Bail B, Arena U, Craxì A, de Ledinghen V. Improved Noninvasive prediction of Liver Fibrosis by Liver Stiffness Measurement in Patients with Nonalcoholic Fatty Liver Disease Accounting for Controlled Attenuation Parameter Values. Hepatology. 2016 Sep 17. doi: 10.1002/hep.28843. [Epub ahead of print]

Cassinotto C, Boursier J, de Lédinghen V, Lebigot J, Lapuyade B, Cales P, Hiriart JB, Michalak S, Bail BL, Cartier V, Mouries A, Oberti F, Fouchard-Hubert I, Vergniol J, Aubé C. Liver stiffness in nonalcoholic fatty liver disease: A comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy. Hepatology. 2016 Jun;63(6):1817-27.

Sempoux C, Paradis V, Komuta M, Wee A, Calderaro J, Balabaud C, Quaglia A, Bioulac-Sage P. Hepatocellular nodules expressing markers of hepatocellular adenomas in Budd-Chiari syndrome and other rare hepatic vascular disorders. J Hepatol. 2015 Nov;63(5):1173-80.

Nault JC, Datta S, Imbeaud S, Franconi A, Mallet M, Couchy G, Letouzé E, Pilati C, Verret B, Blanc JF, Balabaud C, Calderaro J, Laurent A, Letexier M, Bioulac-Sage P, Calvo F, Zucman-Rossi J. Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas. Nat Genet. 2015 Oct;47(10):1187-93.

Pilati C, Letouzé E, Nault JC, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G, Mallet M, Taouji S, Balabaud C, Terris B, Canal F, Paradis V, Scoazec JY, de Muret A, Guettier C, Bioulac-Sage P, Chevet E, Calvo F, Zucman-Rossi J. Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell. 2014 Apr 14;25(4):428-41.

Updated on 29/11/2020