Team 2 - Helicobacter infection: Inflammation and Cancer

Team 2 research is dedicated to the study of the pathogenicity of Helicobacter, in particular in the context of digestive cancers associated to Helicobacter infection: Helicobacter pylori infection in gastric MALT lymphoma and adenocarcinoma, as well as enterohepatic Helicobacter infection in hepatic and intestinal carcinogenesis.

Team leader

Philippe LEHOURS, PU-PH
philippe.lehours@u-bordeaux.fr
+33 (0)5 57 57 12 86

Research description

Our project focuses on the study of Helicobacter pylori and enterohepatic Helicobacters infection and their consequences.

Helicobacter pylori is a Gram negative, microaerophilic bacterium which colonizes human gastric mucosa. H. pylori infection is responsible for at least 90% of non cardia gastric cancers and is the third cause of mortality by cancer in the world with nearly 1 million new cases per year. H. pylori infection consistently induces a chronic inflammation of the gastric mucosa. By its long-life gastric chronic inflammation, H. pylori infection, like other pathogens, could worsen Alzheimer’s disease pathology by increasing neuroinflammation and inducing vascular lesions. Many enterohepatic Helicobacters secrete the Cytolethal Distending Toxin (CDT). CDTs are widely distributed among many pathogenic Gram-negative bacteria. CDT is involved in the severity of the diseases caused by these bacteria and many properties of this toxin support the likelihood of its involvement in cancers.

Our team's aim is to investigate the inflammatory and cellular responses during Helicobacter infections and, in particular, in the context of cancer development.

Our team is linked to the National Reference Center for Campylobacters and Helicobacters.

Our main research axes:

Gastric MALT lymphoma and in particular on inflammatory and molecular responses in animal model of gastric MALT lymphoma development (Philippe Lehours)
Cancer stem cells (CSC) at the origin of the gastric adenocarcinoma (Christine Varon & Emilie Bessède).
Enterohepatic Helicobacters and role of the genotoxin Cytolethal Distending Toxin in cellular remodeling (Armelle Ménard).
Role of H. pylori infection in the progression of Alzheimer’s disease (Nathalie Salles & Claire Roubaud-Baudron)

Publications

2020

Molina-Castro SE, Tiffon C, Giraud J, Boeuf H, Sifre E, Giese A, Belleannée G, Lehours P, Bessède E, Mégraud F, Dubus P, Staedel C, Varon C. The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa. Cell Mol Gastroenterol Hepatol. 2020;9(2):257-276.

Jehanne Q, Pascoe B, Bénéjat L, Ducournau A, Buissonnière A, Mourkas E, Mégraud F, Bessède E, Sheppard SK, Lehours P. Genome-wide identification of host-segregating SNPs for source attribution of clinical Campylobacter coli isolates. Appl Environ Microbiol. 2020 Oct 9:AEM.01787-20.

Courtois S, Haykal M, Bodineau C, Sifré E, Azzi-Martin L, Ménard A, Mégraud F, Lehours P, Durán RV, Varon C, Bessède E. Autophagy induced by Helicobacter pylori infection is necessary for gastric cancer stem cell emergence. Gastric Cancer. 2020 Sep 17.

Blosse A, Peru S, Levy M, Marteyn B, Floch P, Sifré E, Giese A, Prochazkova-Carlotti M, Azzi Martin L, Dubus P, Mégraud F, Ruskone Fournestraux A, Fabiani B, Copie Bergman C, Robe C, Hahne M, Huard B, Lehours P. APRIL-producing eosinophils are involved in gastric MALT lymphomagenesis induced by Helicobacter sp infection. Sci Rep. 2020 Sep 9;10(1):14858.

Seeneevassen L, Giraud J, Molina-Castro S, Sifré E, Tiffon C, Beauvoit C, Staedel C, Mégraud F, Lehours P, Martin OCB, Boeuf H, Dubus P, Varon C.Leukaemia Inhibitory Factor (LIF) Inhibits Cancer Stem Cells Tumorigenic Properties through Hippo Kinases Activation in Gastric Cancer. Cancers (Basel). 2020 Jul 22;12(8):2011.

Tiffon C, Giraud J, Molina-Castro SE, Peru S, Seeneevassen L, Sifré E, Staedel C, Bessède E, Dubus P, Mégraud F, Lehours P, Martin OCB, Varon C. TAZ ControlsHelicobacter pylori-Induced Epithelial-Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties. Cells 2020 Jun 13;9(6):1462.

Giraud J, Molina-Castro S, Seeneevassen L, Sifré E, Izotte J, Tiffon C, Staedel C, Boeuf H, Fernandez S, Barthelemy P, Megraud F, Lehours P, Dubus P, Varon C. Verteporfin targeting YAP1/TAZ-TEAD transcriptional activity inhibits the tumorigenic properties of gastric cancer stem cells. Int J Cancer. 2020 Apr 15;146(8):2255-2267.

Péré-Védrenne C, He W, Azzi-Martin L, Prouzet-Mauléon V, Buissonnière A, Cardinaud B, Lehours P, Mégraud F, Grosset CF, Ménard A. The Nuclear Remodeling Induced by Helicobacter Cytolethal Distending Toxin Involves MAFB Oncoprotein. Toxins (Basel). 2020 Mar 12;12(3):174.

Albaret G, Sifré E, Floch P, Laye S, Aubert A, Dubus P, Azzi-Martin L, Giese A, Salles N, Mégraud F, Varon C, Lehours P, Roubaud-Baudron C. Alzheimer'sDisease and Helicobacter pylori Infection: Inflammation from Stomach to Brain? J Alzheimers Dis. 2020;73(2):801-809.

2019

Azzi-Martin L, He W, Péré-Védrenne C, Korolik V, Alix C, Prochazkova-Carlotti M, Morel JL, Le Roux-Goglin E, Lehours P, Djavaheri-Mergny M, Grosset CF, Varon C, Dubus P, Ménard A. Cytolethal distending toxin induces the formation of transient messenger-rich ribonucleoprotein nuclear invaginations in surviving cells. PLoS Pathog. 2019 Sep 30;15(9):e1007921.

Giraud J, Bouriez D, Seeneevassen L, Rousseau B, Sifré E, Giese A, Mégraud F, Lehours P, Dubus P, Gronnier C, Varon C. Orthotopic Patient-Derived Xenografts of Gastric Cancer to Decipher Drugs Effects on Cancer Stem Cells and Metastatic Dissemination. Cancers (Basel). 2019 Apr 19;11(4).

Courtois S, Lehours P, Bessède E. The therapeutic potential of metformin in gastric cancer. Gastric Cancer. 2019 Mar 21. doi: 10.1007/s10120-019-00952-w.

Lauener FN, Imkamp F, Lehours P, Buissonnière A, Benejat L, Zbinden R, Keller PM, Wagner K. Genetic Determinants and Prediction of Antibiotic Resistance Phenotypes in Helicobacter pylori. J Clin Med. 2019 Jan 7;8(1).

2018

Bouriez D, Giraud J, Gronnier C, Varon C. Efficiency of All-Trans Retinoic Acid on Gastric Cancer: A Narrative Literature Review. Int. J. Mol. Sci. 2018, 19(11), 3388 Published: 29 October 2018.

Courtois S, Bénéjat L, Izotte J, Mégraud F, Varon C, Lehours P, Bessède E. Metformin can inhibit Helicobacter pylori growth. Future Microbiol. 2018 Nov;13:1575-1583.

Kedra J, Zeller V, Heym B, Lehours P, Meyssonnier V, Lariven S, Bruhl-Bénéjat L, Marmor S, Ziza JM. A Case Of Recurrent Helicobacter cinaedi Prosthetic Joint Infection In An HIV-Infected Man. J Bone Jt Infect. 2018 Oct 4;3(4):230-233.

Blosse A, Lehours P, Wilson KT, Gobert AP. Helicobacter: Inflammation, immunology, and vaccines. Helicobacter. 2018 Sep;23 Suppl 1:e12517.

Bénéjat L, Ducournau A, Lehours P, Mégraud F. Real-time PCR for Helicobacter pylori diagnosis. The best tools available. Helicobacter. 2018 Oct;23(5):e12512.

Vale FF, Lehours P. Relating Phage Genomes to Helicobacter pylori Population Structure: General Steps Using Whole-Genome Sequencing Data. Int J Mol Sci. 2018 Jun 21;19(7).

Lehours P. Actual diagnosis of Helicobacter pylori infection. Minerva Gastroenterol Dietol. 2018 Sep;64(3):267-279.

Hays C, Burucoa C, Lehours P, Tran CT, Leleu A, Raymond J. Molecular characterization of Helicobacter pylori resistance to rifamycins. Helicobacter. 2018 Feb;23(1).

Berthenet E, Yahara K, Thorell K, Pascoe B, Meric G, Mikhail JM, Engstrand L, Enroth H, Burette A, Megraud F, Varon C, Atherton JC, Smith S, Wilkinson TS, Hitchings MD, Falush D, Sheppard SK. A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk. BMC Biol. 2018 Aug 2;16(1):84.

Mégraud F. Antibiotic Resistance Is the Key Element in Treatment of Helicobacter pylori Infection. Gastroenterology. 2018 Nov;155(5):1300-1302.
Skrebinska S, Mégraud F, Bessède E. Diagnosis of Helicobacter pylori infection. Helicobacter. 2018 Sep;23 Suppl 1:e12515.

Bachir M, Allem R, Benejat L, Tifrit A, Medjekane M, Drici AE, Megraud F, Douidi KT. Molecular detection of mutations involved in Helicobacter pylori antibiotic resistance in Algeria. J Antimicrob Chemother. 2018 Aug 1;73(8):2034-2038.

Tepes B, Kastelic M, Vujasinovic M, Lampic P, Seruga M, Jurecic NB, Nyssen OP, Donday MG, O'Morain C, Megraud F, McNicholl AG, Gisbert JP. Helicobacter Pylori Treatment Results in Slovenia in the Period 2013-2015 as a Part of European Registry on Helicobacter Pylori Management. Radiol Oncol. 2017 Dec 7;52(1):1-6.

Shield KD, Marant Micallef C, de Martel C, Heard I, Megraud F, Plummer M, Vignat J, Bray F, Soerjomataram I. New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis. Eur J Epidemiol. 2018 Mar;33(3):263-274.

2017

Courtois S, Durán RV, Giraud J, Sifré E, Izotte J, Mégraud F, Lehours P, Varon C, Bessède E. Metformin targets gastric cancer stem cells. Eur J Cancer. 2017 Oct;84:193-201.

Péré-Védrenne C, Prochazkova-Carlotti M, Rousseau B, He W, Chambonnier L, Sifré E, Buissonnière A, Dubus P, Mégraud F, Varon C, Ménard A. The cytolethal distending toxin subunit CdtB of Helicobacter hepaticus promotes senescence and endoreplication in xenograft mouse models of hepatic and intestinal cell lines. Front Cell Infect Microbiol. 2017. June; 7(268):1-12.

Floch P, Capdevielle C, Staedel C, Izotte J, Sifré E, Laur AM, Giese A, Korolik V, Dubus P, Mégraud F, Lehours P. Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model of Helicobacter pylori Infection. Front Cell Infect Microbiol. 2017 May 16;7:185.

Floch P, Izotte J, Guillemaud J, Sifré E, Costet P, Rousseau B, Laur AM, Giese A, Korolik V, Mégraud F, Dubus P, Hahne M, Lehours P. A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species. Am J Pathol. 2017 Apr 28. pii: S0002-9440(17)30031-7.

Floch P, Mégraud F, Lehours P. Helicobacter pylori Strains and Gastric MALT Lymphoma. Toxins (Basel). 2017 Apr 8;9(4).

Vale FF, Nunes A, Oleastro M, Gomes J, Sampaio D, Rocha R, Vítor J, Engstrand L, Pascoe B, Berthenet E, Sheppard S, Hitchings M, Mégraud F, Vadivelu J, Lehours P. Genomic structure and insertion sites of Helicobacter pylori prophages from various geographical origins. Sci Rep. 2017 Feb 16;7:42471.

Nguyen PH, Giraud J, Chambonnier L, Dubus P, Wittkop L, Belleannée G, Collet D, Soubeyran I, Evrard S, Rousseau B, Senant-Dugot N, Mégraud F, Mazurier F and Varon C. Characterization of biomarkers of tumorigenic and chemoresistant cancer stem cells in human gastric carcinoma. Clinical Cancer Research. 2017 Mar 15;23(6):1586-1597.

Péré-Védrenne C, Flahou B, Loke MF, Ménard A, Vadivelu J. Other Helicobacters, gastric and gut microbiota. Helicobacter. 2017 Sep;22 Suppl 1. doi: 10.1111/hel.12407. Review.

2016

F Mégraud, P Lehours, FF Vale. The history of Helicobacter pylori: from phylogeography to paleomicribiology. Clin Microb Infect. 2016 Clin Microbiol Infect. 2016 Nov;22(11):922-927. Review.

Bessède E., Molina-Castro S., Staedel C., L. Acuna-Amador, Dubus P., Tsuchiya M., Chambonnier L., Belleannée G., Buissonière A., Giese A., Mégraud F., Varon C. Deletion of IQGAP1 promotes Helicobacter pylori-induced gastric dysplasia in mice and acquisition of cancer stem cell properties in vitro.Oncotarget. 2016 Dec 6;7(49):80688-80699.

Laur AM, Floch P, Chambonnier L, Benejat L, Korolik V, Giese A, Dubus P, Mégraud F, Bandeira A, Lehours P. Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model. Oncotarget. 2016 Jan 19;7(3):3394-402.

Nguyen PH, Giraud J, Staedel C, Chambonnier L, Dubus P, Chevret E, Gauthereau X, Bœuf H, Rousseau B, Fevre M, Soubeyran I, Belleannée G, Evrard S, Collet D, Mégraud F, Varon C. All-trans retinoic acid targets cancer stem cells in patient’s derived primary gastric carcinoma and inhibits tumor growth. Oncogene. 2016 Oct 27;35(43):5619-5628.

Péré-Védrenne C, Cardinaud B, Varon C, Mocan I, Buissonnière A, Izotte J, Mégraud F, Ménard A. The Cytolethal Distending Toxin Subunit CdtB of Helicobacter Induces a Th17-related and Antimicrobial Signature in Intestinal and Hepatic Cells In Vitro. The Journal of Infectious Disease. 2016 Jun 15;213(12):1979-89.

Ménard A, Buissonnière A, Prouzet-Mauléon V, Sifré E, Mégraud F. The GyrA encoded gene: A pertinent marker for the phylogenetic revision of Helicobacter genus. Systematic and Applied Microbiology. 2016 Mar;39(2):77-87.

Roubaud Baudron C., Varon C., Mégraud F., Salles N. Alzheimer's disease and Helicobacter pylori infection: a possible link?. Geriatr Psychol Neuropsychiatr Vieil. 2016 Mar;14(1):86-94.

Maixner F, Krause-Kyora B, Turaev D, Herbig A, Hoopmann MR, Hallows JL, Kusebauch U, Vigl EE, Malfertheiner P, Megraud F, O'Sullivan N, Cipollini G, Coia V, Samadelli M, Engstrand L, Linz B, Moritz RL, Grimm R, Krause J, Nebel A, Moodley Y, Rattei T, Zink A. The 5300-year-old Helicobacter pylori genome of the Iceman. Science. 2016 Jan 8;351(6269):162-5.

Ducournau A, Bénéjat L, Sifré E, Bessède E, Lehours P, Mégraud F. Helicobacter pylori resistance to antibiotics in 2014 in France detected by phenotypic and genotypic methods. Clin Microbiol Infect. 2016 Aug;22(8):715-8.

Mégraud F, Benejat L, Lehours L. Molecular approaches to identify H. pylori antimicrobial resistance. Gastroenterology Clinics of North America. 2015. Sep;44(3):577-96.

2015

Yemmen M., Nguyen P.H., Trabelsi Ayadi M., Mégraud F., Varon C. Antiproliferative and proapoptotic effects of leaf, fruit and stem extracts of Pistacia lentiscus on human colon and gastric cancer cell lines. International Journal of Advances in Pharmacy, Biology and Chemistry. 2015 Oct-Dec; 4(4):737-745.

Staedel C., Varon C., Nguyen P.H., Vialet B., Chambonnier L., Rousseau B., Soubeyran I., Evrard S., Couillaud F., Darfeuille F. Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specifc, Long-lasting MicroRNA Inhibitors. Molecular Therapy—Nucleic Acids. 2015 Jul 7;4:e246.

Baudron CR, Chambonnier L, Buissionnière A, Giese A, Macrez N, Cho Y, Fénelon V, Blaszczyk L, Dubus P, Lehours P, Mégraud F, Salles N, Varon C. An Eighteen-Month Helicobacter Infection Does Not Induce Amyloid Plaques or Neuroinflammation in Brains of Wild Type C57BL/6J Mice. J Alzheimers Dis. 2015;45(4):1045-50.

Floch P, Laur AM, Korolik V, Chrisment D, Cappellen D, Idrissi Y, Dubus P, Mégraud F, Lehours P. Characterisation of inflammatory processes in Helicobacter pylori-induced gastric lymphomagenesis in a mouse model. Oncotarget. 2015 Oct 27;6(33):34525-36.

Vale F, Vadivelu J, Oleastro M, Breurec S, Engstrand L, Perets TT, Mégraud F, Lehours P. Dormant phages of Helicobacter pylori reveal distinct human populations in Europe. Sci. Rep. 2015. 5, 14333.

Ontsira Ngoyi EN, Atipo Ibara BI, Moyen R, Ahoui Apendi PC, Ibara Obengui JR, Ossibi Ibara RB, Nguimbi E, Niama RF, Ouamba JM, Yala F, Abena A, Vadivelu J, Goh KL, Ménard A, Bénéjat L, Sifré A, Lehours P, Mégraud F. Molecular detection of Helicobacter pylori and its antimicrobial resistance in Brazzaville Congo. Helicobacter. 2015 Aug;20(4):316-20.

Bessède E, Dubus P, Mégraud F, Varon C. Helicobacter pylori infection and stem cells at the origin of gastric cancer.Oncogene. 2015 May 14;34(20):2547-2555.

Mégraud F, Bessède E, Varon C. Helicobacter pylori infection and gastric carcinoma.Clin Microbiol Infect. 2015; Jun 15. doi: 10.1016/j.cmi.2015.06.004.

Roubaud Baudron C, Varon C, Mégraud F, Salles N. Alzheimer’s disease: the infectious hypothesis.Geriatr Psychol Neuropsychiatr Vieil 2015 Dec;13(4):418-24.

Borges V, Santos A, Correia CB, Saraiva M, Ménard A, Vieira L, Sampaio DA, Pinheiro M, Gomes JP, Oleastro M. Helicobacter pullorum isolated from fresh chicken meat: antibiotic resistance and genomic traits of an emerging foodborne pathogen. 2015. Appl Environ Microbiol. 2015 Dec;81(23):8155-63.

Main publications before 2015

Bessède E, Staedel C, Acuña Amador LA, Nguyen PH, Chambonnier L, Hatakeyama M, Belleannée G, Mégraud F, Varon C. Helicobacter pylori generates cells with cancer stem cell properties via epithelial-mesenchymal transition-like changes.Oncogene. 2014 Aug 7;33(32):4123-31.

Varon C, Mocan I, Mihi B, Péré-Védrenne C, Aboubacar A, Moraté C, Oleastro M, Doignon F, Laharie D, Mégraud F, Ménard A. Helicobacter pullorum cytolethal distending toxin targets vinculin and cortactin and triggers formation of lamellipodia in intestinal epithelial cells.J Infect Dis. 2014 Feb 15;209(4):588-99.

Chrisment D, Dubus P, Chambonnier L, Hocès de la Guardia A, Sifré E, Giese A, Capone M, Khairallah C, Costet P, Rousseau B, Hubert C, Burlen-Defranoux O, Varon C, Bandeira A, Mégraud F, Lehours P. Neonatal thymectomy favors Helicobacter pylori-promoted gastric mucosa-associated lymphoid tissue lymphoma lesions in BALB/c mice. Am J Pathol. 2014 Aug;184(8):2174-84.

Hocès de la Guardia A, Staedel C, Kaafarany I, Clément A, Roubaud Baudron C, Mégraud F, Lehours P. Inflammatory cytokine and microRNA responses of primary human dendritic cells cultured with Helicobacter pylori strains. Front Microbiol. 2013 Aug 20;4:236

Varon C, Dubus P, Mazurier F, Asencio C, Chambonnier L, Ferrand J, Giese A, Senant-Dugot N, Carlotti M, Mégraud F. Helicobacter pylori infection recruits bone marrow-derived cells that participate in gastric preneoplasia in mice. Gastroenterology. 2012 Feb;142(2):281-91.

Bessède E, Copie-Bergman C, Lehours P, Levy M, Leroy K, Baia M, Riou A, Mégraud F, Delchier JC, Salles N. Is elevated gastric tissue NOX2 associated with lymphoma of mucosa-associated lymphoid tissue? Antioxid Redox Signal. 2012 Jun 1;16(11):1205-11.

Bernarde C, Lehours P, Lasserre JP, Castroviejo M, Bonneu M, Mégraud F, Ménard A. Complexomics study of two Helicobacter pylori strains of two pathological origins: potential targets for vaccine development and new insight in bacteria metabolism. Mol Cell Proteomics. 2010 Dec;9(12):2796-826.

Lehours P, Zheng Z, Skoglund A, Mégraud F, Engstrand L. Is there a link between the lipopolysaccharide of Helicobacter pylori gastric MALT lymphoma associated strains and lymphoma pathogenesis? PLoS One. 2009 Oct 6;4(10):e7297.

Varon C, Duriez A, Lehours P, Ménard A, Layé S, Zerbib F, Mégraud F, Laharie D. Study of Helicobacter pullorum proinflammatory properties on human epithelial cells in vitro.Gut. 2009 May;58(5):629-35.

Pellicano R, Ménard A, Rizzetto M, Mégraud F. Helicobacter species and liver diseases: association or causation? Lancet Infect Dis. 2008 Apr;8(4):254-60.

Oleastro M, Cordeiro R, Ferrand J, Nunes B, Lehours P, Carvalho-Oliveira I, Mendes AI, Penque D, Monteiro L, Mégraud F, Ménard A. Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease. J Infect Dis. 2008 Nov 1;198(9):1379-87.

Lehours P, Dupouy S, Bergey B, Ruskoné-Foumestraux A, Delchier JC, Rad R, Richy F, Tankovic J, Zerbib F, Mégraud F, Ménard A. Identification of a genetic marker of Helicobacter pylori strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type. Gut. 2004 Jul;53(7):931-7.

Lehours P, Ménard A, Dupouy S, Bergey B, Richy F, Zerbib F, Ruskoné-Fourmestraux A, Delchier JC, Mégraud F. Evaluation of the association of nine Helicobacter pylori virulence factors with strains involved in low-grade gastric mucosa-associated lymphoid tissue lymphoma. Infect Immun. 2004 Feb;72(2):880-8.

Team members

member	status	affiliation
AZZI-MARTIN Lamia	Engineer	University of Bordeaux
BESSÈDE Emilie	MCU-PH	University Hospital of Bordeaux
BLOSSE Alice	AHU, PhD student	University Hospital of Bordeaux
BRUHL-BÉNÉJAT Lucie	Engineer	Hospital of Bordeaux
DUBUS Pierre	PU-PH	University Hospital of Bordeaux
DUCOURNAU Astrid	Assistant-Engineer	Hospital of Bordeaux
GIESE Alban	Assistant-Engineer	University of Bordeaux
GRONNIER Caroline	MCU-PH	University Hospital of Bordeaux
GUIGNARD Jérome	Technician	INSERM
LEHOURS Philippe	PU-PH	University Hospital of Bordeaux
MÉGRAUD Francis	PU-PH	University Hospital of Bordeaux
MÉNARD Armelle	Research Engineer	University Hospital of Bordeaux
NEHME-PELLUARD Fanny	MCU-PH	University Hospital of Bordeaux
ROUBAUD-BAUDRON Claire	MCU-PH	University Hospital of Bordeaux
SALLES Nathalie	PU-PH	University Hospital of Bordeaux
SEENEEVASSEN Lornella	PhD student	University of Bordeaux
SIFRÉ Elodie	Assistant-Engineer	University of Bordeaux
TIFFON Camille	PhD student	University of Bordeaux
VARON Christine	Professor	University of Bordeaux

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Updated on 27/01/2022