Group V. Moreau

Our research focuses on the molecular bases of hepatic tumor cell invasion.

© Violaine Moreau © Violaine Moreau

Research

Reorganization of the actin cytoskeleton is important for cell migration, cell shape change, and interactions with other cells and the environment. Abnormal cell migration and invasion is a characteristic of malignant cancer cells and is one component of metastasis, the major clinical problem in cancer. Consequently, alterations in cytoskeletal signalling pathways are increasingly being recognized as important for cancer invasion and metastasis. Our group uses a wide range of biochemical, cell biological methods and animal models to study how actin cytoskeleton is regulated and involved in hepatocellular carcinoma cell invasion.

Our work focuses on the involvement of RhoGTPases and regulators in hepatic tumor cell invasion.

We have documented the frequent down-regulation of RhoE/Rnd3 in hepatocellular carcinoma and shown that it behaves as a suppressor of invasion. We aim at better understanding its mechanisms of action and regulation in liver tumor cells.

Based on cancer-associated mutations, we study the involvement of p190RhoGAP, a negative regulator of Rho GTPases, in cancer cell migration.

 

People

 

Main publications

Updated on 25/06/2018

Group leader

Contact

Violaine MOREAU
DR2 INSERM

+33 (0)5 57 57 12 72
Contact by email