Group F. Saltel

The overall project is to identify, at cellular and tissue levels, molecular pathways involved in tumor progression.

© Fred Saltel © Fred Saltel

Research

Metastases development at a distance from a primary site of cancer represents the principal cause of cancer-related mortality. Presently, there is no efficient way to block tumor cell invasion. Significantly, cell invasion relates only to a small part of the tumor and is linked to invasive structures named invadosomes consisting of invasive protrusions that orchestrate tumor cell invasion. Recently, in my group we developed a new methodology to define the proteome of low biological material obtained from subcellular compartment and adapted it to human tissues (hepatocellular carcinoma).

Our work focuses on the link between the matrix tumor microenvironment and cancer cell invasion

Two principal research axes:

• DDR 1 and 2 involvement in tumor progression and invasion
• Translational research on liver tumors using proteomic approach

We highlighted :
• a new organization of invadosomes induced by the type I collagen into its fibrillar organization
• the concept of invadosomes plasticity

Discoidin receptor 1 controls linear invadosome formation and activity.

 

Video: Tumor cell (blue) seeded on type I collagen fibrils (red) forming linear invadosomes labelled by Tks5 (green)

 

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Updated on 05/06/2018

Group Leader

Contact

Frédéric Saltel
CR1 INSERM

+33(0)5 57 57 17 07
Contact by email