Team 3 - Oncogenesis of cutaneous lymphomas

Cutaneous lymphoma as a general model to study lymphoid cells oncogenesis

Team leader

Jean-Philippe MERLIO, PU-PH
jp.merlio@u-bordeaux.fr
+33 (0)5 57 57 10 27

Research description

Cutaneous lymphomas are a fascinating cancer subtype with analysis at different disease’s stages. Our team involves clinicians and researchers working in the Dermatology, Pathology and Tumor Genetic Departments of Bordeaux University Hospital with coordination of the Cancer Biobank. We are the regional reference center of the French Study Group on Cutaneous Lymphoma, a National network whose database is hosted in Bordeaux and an EORTC trial center.

Focusing on the most aggressive cutaneous lymphomas, we aim at understanding which genetic alteration and mechanisms are driving their oncogenesis to establish new diagnostic, prognostic or predictive biomarkers.

At the translational level, we are setting up functional and experimental assays to analyze the lymphoma cell hallmarks such as proliferation, apoptosis resistance, migration and invasion.

Each principal investigator with its students develops its own project such as deciphering telomerase functions in aggressive T-cell lymphomas, modeling chromosomal or genetic mutations in genetically-modified cells and establishing patients-derived long-term cultures and xenografts. These models are used to assess the role of adhesion molecules and chemoreceptors in cell migration or to test therapeutic intervention or RNA interference of selected genes.

Publications

Publications 2019

Cappellen D, Balabaud C, Bioulac-Sage P. A difficult case of β-catenin-mutated hepatocellular adenoma: a lesson for diagnosis.Histopathology. 2019 Jan;74(2):355-357. doi: 10.1111/his.13751. Epub 2018 Dec 6. No abstract available.

Latour S, Zanese M, Le Morvan V, Vacher AM, Menard N, Bijou F, Durrieu F, Soubeyran P, Savina A, Vacher P, Bresson-Bepoldin L. Role of Calcium Signaling in GA101-Induced Cell Death in Malignant Human B Cells.Cancers (Basel). 2019 Mar 1;11(3). pii: E291. doi: 10.3390/cancers11030291.

Leroy V, Gerard E, Dutriaux C, Prey S, Gey A, Mertens C, Beylot-Barry M, Pham-Ledard A. Adverse events need for hospitalization and systemic immunosuppression in very elderly patients (over 80 years) treated with ipilimumab for metastatic melanoma.Cancer Immunol Immunother. 2019 Apr;68(4):545-551. doi: 10.1007/s00262-019-02298-9. Epub 2019 Jan 19.

Ducharme O, Beylot-Barry M, Pham-Ledard A, Bohers E, Viailly PJ, Bandres T, Faur N, Frison E, Vergier B, Jardin F, Merlio JP, Gros A. Mutations of the B-cell receptor pathway confer chemoresistance in primary cutaneous diffuse large B-cell lymphoma leg-type.J Invest Dermatol. 2019 May 28. pii: S0022-202X(19)31572-6. doi: 10.1016/j.jid.2019.05.008. [Epub ahead of print]

Soulages A, Tang HM, Pham-Ledard A, Négrier-Leibreich ML, Cosnard A, Duval F, Solé G, Carla L, Le Masson G, Mathis S. Myopathy and scleromyxedema.J Neurol. 2019 May 21. doi: 10.1007/s00415-019-09379-w. [Epub ahead of print]

Menguy S, Beylot-Barry M, Parrens M, Ledard AP, Frison E, Comoz F, Battistella M, Szablewski V, Balme B, Croue A, Franck F, Ortonne N, Tournier E, Lamant L, Carlotti A, De Muret A, Le Gall F, Lorton MH, Merlio JP, Vergier B. Primary cutaneous large B-cell lymphomas: relevance of the 2017 World Health Organization classification: clinicopathological and molecular analyses of 64 cases.Histopathology. 2019 Jun;74(7):1067-1080. doi: 10.1111/his.13832. Epub 2019 Apr 25.

Blaizot R, Fernandez P, Cogrel O, Beylot-Barry M, Pham-Ledard A. Three cases of bacterial osteomyelitis associated with hidradenitis suppurativa.Br J Dermatol. 2019 Jun;180(6):1537-1538. doi: 10.1111/bjd.17593. Epub 2019 Feb 4. No abstract available.

Couraud S, Barlesi F, Fontaine-Deraluelle C, Debieuvre D, Merlio JP, Moreau L, Beau-Faller M, Veillon R, Mosser J, Al Freijat F, Bringuier PP, Léna H, Ouafik L, Westeel V, Morel A, Audigier-Valette C, Missy P, Langlais A, Morin F, Souquet PJ, Planchard D; Biomarkers France Contributors. Clinical outcomes of non-small-cell lung cancer patients with BRAF mutations: results from the French Cooperative Thoracic Intergroup biomarkers France study.Eur J Cancer. 2019 Jun 7; 116:86-97. doi: 10.1016/j.ejca.2019.04.016. [Epub ahead of print]

Publications 2018

Delyon J, Chevret S, Jouary T, Dalac S, Dalle S, Guillot B, Arnault JP, Avril MF, Bedane C, Bens G, Pham-Ledard A, Mansard S, Grange F, Machet L, Meyer N, Legoupil D, Saiag P, Idir Z, Renault V, Deleuze JF, Hindie E, Battistella M, Dumaz N, Mourah S, Lebbe C; GCC (French Group of Skin Cancer). STAT3 Mediates Nilotinib Response in KIT-Altered Melanoma: A Phase II Multicenter Trial of the French Skin Cancer Network.J Invest Dermatol. 2018 Jan;138(1):58-67. doi: 10.1016/j.jid.2017.07.839. Epub 2017 Aug 24.

Pierry C, Caumont C, Blanchard E, Brochet C, Dournes G, Gros A, Bandres T, Verdon S, Marty M, Bégueret H, Merlio JP. Assessment of BRAFV600E mutation in pulmonary Langerhans cell histiocytosis in tissue biopsies and bronchoalveolar lavages by droplet digital polymerase chain reaction.Virchows Arch. 2018 Feb;472(2):247-258. doi: 10.1007/s00428-017-2185-0. Epub 2017 Jul 15.

Menguy S, Prochazkova-Carlotti M, Beylot-Barry M, Saltel F, Vergier B, Merlio JP, Pham-Ledard A. PD-L1 and PD-L2 Are Differentially Expressed by Macrophages or Tumor Cells in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type.Am J Surg Pathol. 2018 Mar;42(3):326-334. doi: 10.1097/PAS.0000000000000983.

Kostine M, Rouxel L, Barnetche T, Veillon R, Martin F, Dutriaux C, Dousset L, Pham-Ledard A, Prey S, Beylot-Barry M, Daste A, Gross-Goupil M, Lallier J, Ravaud A, Forcade E, Bannwarth B, Truchetet ME, Richez C, Mehsen N, Schaeverbeke T; FHU ACRONIM. Rheumatic disorders associated with immune checkpoint inhibitors in patients with cancer-clinical aspects and relationship with tumour response: a single-centre prospective cohort study.Ann Rheum Dis. 2018 Mar;77(3):393-398. doi: 10.1136/annrheumdis-2017-212257. Epub 2017 Nov 16.

Menguy S, Frison E, Prochazkova-Carlotti M, Dalle S, Dereure O, Boulinguez S, Dalac S, Machet L, Ram-Wolff C, Verneuil L, Gros A, Vergier B, Beylot-Barry M, Merlio JP, Pham-Ledard A. Double-hit or dual expression of MYC and BCL2 in primary cutaneous large B-cell lymphomas.Mod Pathol. 2018 Aug;31(8):1332-1342. doi: 10.1038/s41379-018-0041-7. Epub 2018 Mar 26.

Poglio S, Merlio JP. SATB1 Is a Pivotal Epigenetic Biomarker in Cutaneous T-Cell Lymphomas.J Invest Dermatol. 2018 Aug;138(8):1694-1696. doi: 10.1016/j.jid.2018.04.018

Scarisbrick JJ, Quaglino P, Prince HM, Papadavid E, Hodak E, Bagot M, Servitje O, Berti E, Ortiz-Romero P, Stadler R, Patsatsi A, Knobler R, Guenova E, Child F, Whittaker S, Nikolaou V, Tomasini C, Amitay I, Prag Naveh H, Ram-Wolff C, Battistella M, Alberti-Violetti S, Stranzenbach R, Gargallo V, Muniesa C, Koletsa T, Jonak C, Porkert S, Mitteldorf C, Estrach T, Combalia A, Marschalko M, Csomor J, Szepesi A, Cozzio A, Dummer R, Pimpinelli N, Grandi V, Beylot-Barry M, Pham-Ledard A, Wobser M, Geissinger E, Wehkamp U, Weichenthal M, Cowan R, Parry E, Harris J, Wachsmuth R, Turner D, Bates A, Healy E, Trautinger F, Latzka J, Yoo J, Vydianath B, Amel-Kashipaz R, Marinos L, Oikonomidi A, Stratigos A, Vignon-Pennamen MD, Battistella M, Climent F, Gonzalez-Barca E, Georgiou E, Senetta R, Zinzani P, Vakeva L, Ranki A, Busschots AM, Hauben E, Bervoets A, Woei-A-Jin FJSH, Matin R, Collins G, Weatherhead S, Frew J, Bayne M, Dunnill G, McKay P, Arumainathan A, Azurdia R, Benstead K, Twigger R, Rieger K, Brown R, Sanches JA, Miyashiro D, Akilov O, McCann S, Sahi H, Damasco FM, Querfeld C, Folkes A, Bur C, Klemke CD, Enz P, Pujol R, Quint K, Geskin L, Hong E, Evison F, Vermeer M, Cerroni L, Kempf W, Kim Y, Willemze R. The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients.Br J Dermatol. 2018 Sep 29. doi: 10.1111/bjd.17258. [Epub ahead of print]

Beylot-Barry M, Mermin D, Maillard A, Bouabdallah R, Bonnet N, Duval-Modeste AB, Mortier L, Ingen-Housz-Oro S, Ram-Wolff C, Barete S, Dalle S, Maubec E, Quereux G, Templier I, Bagot M, Grange F, Joly P, Vergier B, Vially PJ, Gros A, Pham-Ledard A, Frison E, Merlio JP. A single-arm phase II trial of lenalidomide in relapsing or refractory primary cutaneous large B-cell lymphoma leg-type.J Invest Dermatol. 2018 Sep;138(9):1982-1989. doi: 10.1016/j.jid.2018.03.1516. Epub 2018 Mar 27.

Latour S, Mahouche I, Cherrier F, Azzi-Martin L, Velasco V, Soubeyran P, Merlio JP, Poglio S, Bresson-Bepoldin L. Calcium Independent Effect of Orai1 and STIM1 in Non-Hodgkin B Cell Lymphoma Dissemination.Cancers (Basel). 2018 Oct 26;10(11). pii: E402. doi: 10.3390/cancers10110402.

Dequidt L, Dousset L, Pham-Ledard A, Doutre MS, Beylot-Barry M. Long-lasting cutaneous tuberculosis owing to Mycobacterium bovis masquerading as sarcoidosis.JAAD Case Rep. 2018 Nov 27;5(1):1-4. doi: 10.1016/j.jdcr.2018.07.020. eCollection 2019 Jan. No abstract available.

Blaizot R, Ouattara E, Fauconneau A, Beylot-Barry M, Pham-Ledard A. Infectious events and associated risk factors in mycosis fungoides/Sézary syndrome: a retrospective cohort study.Br J Dermatol. 2018 Dec;179(6):1322-1328. doi: 10.1111/bjd.17073. Epub 2018 Oct 12.

Publications 2017

Gros A, Laharanne E, Vergier M, Prochazkova-Carlotti M, Pham-Ledard A, Bandres T, Poglio S, Berhouet S, Vergier B, Vial JP, Chevret E, Beylot-Barry M, Merlio JP. TP53 alterations in primary and secondary Sézary syndrome: A diagnostic tool for the assessment of malignancy in patients with erythroderma. PLoS One. 2017 Mar 16;12(3):e0173171. doi: 10.1371/journal.pone.0173171. eCollection 2017.

Mareschal S, Pham-Ledard A, Viailly PJ, Dubois S, Bertrand P, Maingonnat C, Fontanilles M, Bohers E, Ruminy P, Tournier I, Courville P, Lenormand B, Duval AB, Andrieu E, Verneuil L, Vergier B, Tilly H, Joly P, Frebourg T, Beylot-Barry M, Merlio JP, Jardin F. Identification of somatic mutations in primary cutaneous diffuse large B-cell lymphomas, leg-type by massive parallel sequencing. J Invest Dermatol. 2017 May 4. pii: S0022-202X(17)31429-X. doi: 10.1016/j/jid.2017-04-010. [epub ahead of print]

Pham-Ledard A, Prochazkova-Carlotti M, Deveza M, Laforet MP, Beylot-Barry M, Vergier B, Parrens M, Feuillard J, Merlio JP, Gachard N. Molecular analysis of immunoglobulin variable genes supports a germinal center experienced normal counterpart in primary cutaneous diffuse large B-cell lymphoma, leg-type.J Dermatol Sci. 2017 Nov;88(2):238-246. doi: 10.1016/j.jdermsci.2017.07.008. Epub 2017 Jul 26.

Publications 2016

Furudoi A, Gros A, Stanislas S, Hamidou M, Furudoi E, Oksenhendler E, Merlio JP, Viallard JF, Parrens M. Spleen histologic appearance in common variable immunodeficiency. American Journal Of Surgical Pathology. 2016 Jul;40(7):958-67. doi: 10.1097/PAS.0000000000000661.

Toutain J, Prochazkova-Carlotti M, Horovitz J, Saura R, Merlio JP, Chevret E. Evaluation of Quantitative Fluorescence in situ Hybridization for relative measurement of telomere length in placental mesenchymal core cells. Gynecologic and Obstetric Investigation. 2016;81(1):54-60. doi: 10.1159/000381896. Epub 2015 May 20.

Furudoï A, Caumont C, Dutriaux C, Cappellen D, Goussot JF, Vergier B, Merlio C, Barberis C, Merlio JP, Gros A. Primary digestive melanoma in association with tubular adenoma : a case report illustrating the distinction from metastatic colonic melanoma. Human pathology. 2016 Feb;48:167-71. doi: 10.1016/j.humpath.2015.09.025. Epub 2015 Oct 9.

Caumont C, Veillon R, Gros A, Laharanne E, Begueret H, Merlio JP. Neuroendocrine phenotype as an acquired resistance mechanism in ALK-rearranged lung adenocarcinoma. Lung Cancer. 2016 Feb;92:15-8. doi: 10.1016/j.lungcan.2015.12.001. Epub 2015 Dec 4.

Andrique L, Poglio S, Prochazkova-Carlotti M, Kadin ME, Giese A, Idrissi Y, Beylot-Barry M, Merlio JP, Chevret E. Intrahepatic Xenograft of Cutaneous T-Cell Lymphoma Cell Lines : a useful model for rapid biological and therapeutic evaluation. American Journal of Pathology. 2016 Jul;186(7):1775-85. doi: 10.1016/j.ajpath.2016.03.012. Epub 2016 May 13.

Chevret E, Merlio JP. Sézary Syndrome : translating genetic diversity into personalized medicine. Journal of Investigative Dermatology. 2016 Jul;136(7):1319-24. doi: 10.1016/j.jid.2016.04.027.

Menguy S, Gros A, Pham-Ledard A, Battistella M, Ortonne N, Comoz F, Balme B, Szablewski V, Lamant L, Carlotti A, Lorton MH, de Muret A, Le Gall F, Franck F, Croue A, Cappellen D, Beylot-Barry M, Merlio JP, Vergier B. MYD88 Somatic Mutation is a diagnostic criterion in primary cutaneous large B-Cell lymphoma. Journal of Investigative Dermatology. 2016 Aug;136(8):1741-4. doi: 10.1016/j.jid.2016.04.018. Epub 2016 May 14.

Mélard P, Idrissi Y, Andrique L, Poglio S, Prochazkova-CarlottiM, Berhouet S, Boucher C, Laharanne E, Chevret E, Pham-Ledard A, De Souza Góes AC, Guyonnet-Duperat V, Bibeyran A, Moreau-Gaudry F, Vergier B, Beylot-Barry M, Merlio JP, Cappellen D. Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes.Oncotarget. 2016 Oct 18;7(42):68734-68748. doi: 10.18632/oncotarget.11930

Vergier B, Laharanne E, Prochakova-Carlotti M, De La Fouchardière A, Merlio JP, Kadlub N, Avril MF, Bodemer C, Lacoste C, Boralevi F, Taieb A, Ezzedine K, Fraitag S. Proliferative nodules vs melanoma arising in giant congenital melanocytic nevi during childhood. JAMA Dermatology. 2016 Oct 1;152(10):1147-1151. doi: 10.1001/jamadermatol.2016.2667.

Ropio J, Merlio JP, Soares P, Chevret E. Telomerase Activation in Hematological Malignancies. Genes (Basel). 2016 Sep 7;7(9). pii: E61. doi: 10.3390/genes7090061.

Cunha KS, Oliveira NS, Fausto AK, de Souza CC, Gros A, Bandres T, Idrissi Y, Merlio JP, de Moura Neto RS, Silva R, Geller M, Cappellen D. Hybridization Capture-Based Next-Generation Sequencing to Evaluate Coding Sequence and Deep Intronic Mutations in the NF1 Gene. Genes (Basel). 2016 Dec 17;7(12). pii: E133. doi: 10.3390/genes7120133.

Publications 2015

Pham-Ledard A, Cowpli-Bonni M, Dousseau A, Prochazkova-Carlotti M, Laharanne E, Jouardy T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M, Diagnostic and Prognosis value of BLC in 53 patients with follicular lymphoma presenting as primary skin lesions Am. J. Clin. Pathol, March 2015.

Fauconneau A, Pham-Ledard A; Cappellen D,Frison E, Prochazkova-Carlotti M, Parrens M, Dalle S, Joly P, Viraben R, Franck F, Ingen-Housz-Oro S, Giacchero D, Jullie ML, Vergier B, Merlio JP, Beylot-Barry M. Assessment of diagnostic criteria between primary cutaneous anaplastic large cell lymphoma and CD30-rich transformed mycosis fungoides. A study of 66 cases. Br J Dermatol, June 2015.

Caumont C, Gros A, Boucher C, Mélard P, Prochazkova-CarlottiM, Laharanne E, Pham-Ledard A, Vergier B, Chevret E, Beylot-Barry M, Merlio JP, Cappellen D. PLCG1 Gene Mutations Are Uncommon in Cutaneous T-Cell Lymphomas. J Invest Dermatol. 2015 April 24.

Laban E, Beylot-Barry M, Ortonne N, Battistella M, Carlotti A, de Muret A, Wechsler J, Balme B, Petrella T, Lamant L, Frouin E, Merlio JP, Vergier B. Cutaneous lymphoproliferations: Proposal for the use of diagnostic algorithms base don 2760 cases of cutaneous lymphoproliferations taken from the INCa networks (LYMPHOPATH and GFELC) over a two-year period. Ann Pathol. 2015 April; 35(2):131-47

Pham-Ledard A, Cowppli-Bony A, Doussau A, Prochazkova-Carlotti M, Laharanne E, Jouary T, Belaud-Rotureau MA, Vergier B, Merlio JP, Beylot-Barry M. Diagnostic and prognostic value of BCL2 rearrangement in 53 patients with folicular lymphoma presenting as primary skin lesions. Am J Clin Pathol. 2015 March; 143(3):362-73.

Fauconneau A, Pham-Ledard A, Cappellen D, Frison E, Prochazkova-Carlotti M, Parrens M, Dalle S, Joly P, Viraben R, Franck F, Ingen-Housz-Oro S, Giacchero D, Jullié ML, Vergier B, Merlio JP, Beylot-Barry M. Assessment of diagnostic criteria between primary cutaneous anaplastic large-cell lymphoma and CD30-rich transformed mycosis fungoides; a study of 66 cases.Br J Dermatol.2015 Jun;172(6):1547-54. doi: 10.1111/bjd.13690. Epub 2015 May 16.

Before 2015

Pham-Ledard A, Prochazkova-Carlotti M, Andrique L, Cappellen D, Vergier B, Martinez F, Grange F, Petrella T, Beylot-Barry M, Merlio JP. Multiple genetic alterations in primary cutaneou large B-cell lymphoma, leg type support a common lymphomagenesis with activated B-cell-like diffuse largeB-cell lymphoma. Modern Pathology. 2013 Sept. 10.138/modpathol.2013.56

Toutain J, Prochazkova-Carlotti M, Cappellen D, Jarne A, Chevret E, Ferrer J, Idrissi Y, Pelluard F, Carles D, Maugey-Laulon B, Lacombe D, HorovitzJ, Merlio JP, Saura R. Reduced placenta telomere length during pregancies complicated by intauterine growth restriction. PLoS One. 2013 Jan. (8(1): e54013

Guillet S, Stokkermans J, Vergier B, Doutre MS, Beylot-Barry M.Acute neutrophilic dermatosis (pustular dermatitis) associated with aggressive transformed mycosis fungoides. Ann Dermatol Venereol. 2013 Oct. 140(10): 635-40

Bertolotti A, Pham-Ledard AL, Vergier B, Parrens M, Bedane C, Beylot-Barry M. Lymphomatoid papulosis type D : an aggressive histology for indolent disease. Br J Dermatol.2013 Nov. 169 (5): 1157-9. doi: 10.1111/bjd.12463. PubMed PMID: 23746266.

Jullié ML, Carlotti M, Vivot A Jr, Beylot-Barry M, Ortonne N, Frouin E, Carlotti A, de Muret A, Balme B, Franck F, Merlio JP, Vergier B. CD20 antigen may be expressed by reactive or lymphomatous cells of transformed micosis fungoides: diagnostic and prognostic impact. Am.J. Surg. Pathol. 2013 Dec. 37(12):1845-54

Chevret E, Andrique L, Prochazkova-Carlotti M, Ferrer J, Cappellen D, Laharanne E, Idrissi Y, Boettiger A,Sahraoui W, Ruiz F, Pham-Ledard A, Vergier B, Belloc F, Dubus P, Beylot-Barry M, Merlio JP. Telomerase functions beyond telomere maintenance in primary cutaneous T-cell lymphoma. Blood. 2014 Mar 20;123(12):1850-9. doi: 10.1182/blood-2013-05-500686. Epub 2014 Jan 27.

Dilly M, Ben-Rejeb H, Vergier B, Toty L, Nohra O, Petrot D, Beylot-Barry M, Merlio JP, Parrens M. Primary cutaneous follicle centre lymphoma with Hodgkin and Reed-Sternberg like cells. J. Cutan. Pathol. 2014 Oct;41(10):797-801. doi: 10.1111/cup.12379. Epub 2014 Oct 18.

Pham-Ledard A, Beylot-Barry M, Barbe C, Leduc M, Petrella T, Vergier B, Martinez F, Cappellen D, Merlio JP, Grange F. Primary cutaneous diffuse large B-cell lymphoma, leg-type: high frequency and clinical prognostic value of MYD88 L265P mutation. JAMA Dermatol. 2014 Nov;150(11):1173-9

Bertolotti A, Pham-Ledard A, Petrot D, Coindre MC, Brecheteau P, Mendes I, Vergier B, Beylot-Barry M.[Two cases of proliferation of monoclonal and monotypic lymphocytes and plasma cells corresponding to acrodermatitis chronica atrophicans].Ann Dermatol Venereol. 2014 Jun-Jul;141(6-7):452-7.

Team members

Member	Status	Affiliation
BEYLOT-BARRY Marie	PU-PH	University Hospital of Bordeaux
BRESSON-BEPOLDIN Laurence	CR	CNRS
CAPPELLEN David	MCU-PH	University of Bordeaux/University Hospital of Bordeaux
CARLOTTI Martina	Engineer	University of Bordeaux
CAUMONT Charline	Hospital Assistant	University Hospital of Bordeaux/University of Bordeaux
CHERRIER Floriane	Technician	University of Bordeaux
CHEVRET Edith	PU	University of Bordeaux
DE MASCAREL Antoine	Professor Emeritus	University Hospital of Bordeaux
GROS Audrey	Hospital Assistant	University Hospital of Bordeaux/university of Bordeaux
IDRISSI Yamina	Technician	University of Bordeaux
MERLIO Jean-Philippe	PU-PH	University of Bordeaux/University Hospital of Bordeaux
PARRENS Marie	PU-PH	University Hospital of Bordeaux
PHAM-LEDARD Anne	HU	University Hospital of Bordeaux
POGLIO Sandrine	MCU	University of Bordeaux
PREVOT Alexandra	Administrative Assistant	University of Bordeaux
VERGIER Béatrice	PU-PH	University Hospital of Bordeaux

Key words :

Updated on 26/11/2020