Team 3 - Oncogenesis of cutaneous lymphomas

Cutaneous lymphoma as a general model to study lymphoid cells oncogenesis

Team leader

Jean-Philippe MERLIO, PU-PH
jp.merlio@u-bordeaux.fr
+33 (0)5 57 57 10 27

 

Research description

Cutaneous lymphomas are a fascinating cancer subtype with analysis at different disease’s stages. Our team involves clinicians and researchers working in the Dermatology, Pathology and Tumor Genetic Departments of Bordeaux University Hospital with coordination of the Cancer Biobank. We are the regional reference center of the French Study Group on Cutaneous Lymphoma, a National network whose database is hosted in Bordeaux and an EORTC trial center.

Focusing on the most aggressive cutaneous lymphomas, we aim at understanding which genetic alteration and mechanisms are driving their oncogenesis to establish new diagnostic, prognostic or predictive biomarkers.

At the translational level, we are setting up functional and experimental assays to analyze the lymphoma cell hallmarks such as proliferation, apoptosis resistance, migration and invasion.

Each principal investigator with its students develops its own project such as deciphering telomerase functions in aggressive T-cell lymphomas, modeling chromosomal or genetic mutations in genetically-modified cells and establishing patients-derived long-term cultures and xenografts. These models are used to assess the role of adhesion molecules and chemoreceptors in cell migration or to test therapeutic intervention or RNA interference of selected genes.

Publications

Team members

Member

Status

Affiliation

BEYLOT-BARRY Marie

PU-PH

University Hospital of Bordeaux

CAPPELLEN David

MCU-PH

University of Bordeaux/University Hospital of Bordeaux

CARLOTTI Martina

Engineer

University of Bordeaux

CAUMONT Charline

Hospital Assistant

University Hospital of Bordeaux/University of Bordeaux

CHERRIER Floriane

Technician

University of Bordeaux

CHEVRET Edith

PU

University of Bordeaux

DE MASCAREL Antoine

Professor Emeritus

University Hospital of Bordeaux

GROS Audrey

Hospital Assistant

University Hospital of Bordeaux/university of Bordeaux

IDRISSI Yamina

Technician

University of Bordeaux

MERLIO Jean-Philippe

PU-PH

University of Bordeaux/University Hospital of Bordeaux

PARRENS Marie

PU-PH

University Hospital of Bordeaux

PHAM-LEDARD Anne

HU

University Hospital of Bordeaux

POGLIO Sandrine

MCU

University of Bordeaux

PREVOT Alexandra

Administrative Assistant

University of Bordeaux

ROPIO Joana

PhD Student

University of Bordeaux/University of Porto

VERGIER Béatrice

PU-PH

University Hospital of Bordeaux

Updated on 12/02/2018