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New publication of Team 1 and Oncoprot in Nature Communications (25 June 2018)

Combining laser capture micro-dissection and proteomics reveals an active translation machinery controlling invadosome formation Zakaria Ezzoukhry#, Elodie Henriet#, Fabrice P. Cordelières, Jean ... The Oncoprot technique helps to reveal an active translation machinery at invadosomes.

Team 1 - Liver Cancer and Tumor Invasion (01 February 2021)

axes: Mediators of liver carcinogenesis (beta-catenin, RhoGTPases, translation factors) Molecular bases of tumor invasion (Invadosomes, Type I Collagen, discoidin domain receptors, Rho ... invasion, liver cancer, actin cytoskeleton, invadosomes, small GTPases, metastases, Rho GTPases, collagen, DDR

Organization of the Unit (10 July 2020)

Cancer, invasion, liver cancer, actin cytoskeleton, invadosomes, metastases, gastric cancer, gastric MALT lymphoma, cancer stem cells, toxins, Helicobacter pylori, Cutaneous lymphomas, telomerase

Presentation of the unit (22 May 2017)

Cancer, invasion, liver cancer, actin cytoskeleton, invadosomes, small GTPases, metastases, Rho GTPases, collagen, DDR, gastric cancer, gastric MALT lymphoma, cancer stem cells, toxins

Team 1 awarded FRM label 2018 (05 September 2018)

This prestigious label is awarded for 3 years on the projet entitled "Deciphering and targeting the invadosome molecular machinery".

V. Moreau received an FRM award for BaRITOn Team #1 (11 November 2019)

is awarded for 3 years on the projet entitled "Deciphering and targeting the invadosome molecular machinery".

New publication of Team 1 in Nature Cell Biology (21 September 2020)

surface into invadosomes, where they help reduce ECM disulfide bonds before ECM clivage by MMPs. We highlighted a new key step in extracellular matrix (ECM) degradation and tumor invasion.   Abstract

Group F. Saltel (01 February 2021)

invasion. Significantly, cell invasion relates only to a small part of the tumor and is linked to invasive structures named invadosomes consisting of invasive protrusions that orchestrate tumor cell invasion

Group V. Moreau (29 November 2020)

: a minimal and universal molecular signature for functional invadosomes.  Cell Adh Migr, 2014, Apr 16;8(3). *,#equal contribution. Bidaud-Meynard A*, Arma D*, Taouji S*, Laguerre M, Dessolin J, Rosenbaum J

Thesis (01 February 2021)

microenvironnement dans la composition, la plasticité et la formation des invadosomes ♦ Joaquim JAVARY Defense date: November, 3rd 2017 PhD director: Jean Rosenbaum/Samira Benhamouche/Violaine Moreau Title: Rôle