Publication from Team 1 in JCB
Regulating Rho GTPases at the right place: lessons from tumors
- 06/04/2017
© JCB / V. Moreau
P190RhoGAP (p190A) is a negative regulator of RhoA and localizes to membrane protrusions, where its GAP activity is required for directional migration. Here, Binamé, Bidaud-Meynard et al. identify the protrusion-localization sequence in p190A and show that cancer-associated mutations in this region affect p190A localization and function as well as tumor cell migration.
related publication: Journal of Cell Biology 2016 Sep 26;214(7):859-73.
related review: Small GTPases 2017 Mar 13:1-12.
